Essential Role for the Mnk Pathway in the Inhibitory Effects of Type I Interferons on Myeloproliferative Neoplasm (MPN) Precursors

The mechanisms of generation of the antineoplastic effects of interferons (IFNs) in malignant hematopoietic cells remain to be precisely defined. We examined the activation of type I IFN-dependent signaling pathways in malignant cells transformed by Jak2V617F, a critical pathogenic mutation in myelo...

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Detalhes bibliográficos
Main Authors: Mehrotra, Swarna, Sharma, Bhumika, Joshi, Sonali, Kroczynska, Barbara, Majchrzak, Beata, Stein, Brady L., McMahon, Brandon, Altman, Jessica K., Licht, Jonathan D., Baker, Darren P., Eklund, Elizabeth A., Wickrema, Amittha, Verma, Amit, Fish, Eleanor N., Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745328/
https://ncbi.nlm.nih.gov/pubmed/23814052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476192
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