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Protein Kinase R as Mediator of the Effects of Interferon (IFN) γ and Tumor Necrosis Factor (TNF) α on Normal and Dysplastic Hematopoiesis

IFNγ and TNFα are potent inhibitors of hematopoiesis and have been implicated in the pathophysiology of bone marrow failure and myelodysplastic syndromes (MDS). We examined the role of protein kinase R (PKR) in the generation of the inhibitory effects of these myelosuppressive cytokines on hematopoi...

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Detalhes bibliográficos
Main Authors: Sharma, Bhumika, Altman, Jessica K., Goussetis, Dennis J., Verma, Amit K., Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149343/
https://ncbi.nlm.nih.gov/pubmed/21659535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.238501
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