Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses

We provide evidence for a unique pathway engaged by the type II IFN receptor, involving mTORC2/AKT-mediated downstream regulation of mTORC1 and effectors. These events are required for formation of the eukaryotic translation initiation factor 4F complex (eIF4F) and initiation of mRNA translation of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kroczynska, Barbara, Rafidi, Robert L., Majchrzak-Kita, Beata, Kosciuczuk, Ewa M., Blyth, Gavin T., Jemielity, Jacek, Warminska, Zofia, Saleiro, Diana, Mehrotra, Swarna, Arslan, Ahmet Dirim, Fish, Eleanor N., Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732221/
https://ncbi.nlm.nih.gov/pubmed/26645692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.664995
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