Regulation of Arsenic Trioxide-induced Cellular Responses by Mnk1 and Mnk2

Arsenic trioxide (As(2)O(3)) is a potent inducer of apoptosis of malignant cells in vitro and in vivo, but the precise mechanisms by which it mediates such effects are not well defined. We provide evidence that As(2)O(3) induces phosphorylation/activation of the MAPK signal-integrating kinases (Mnks...

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Main Authors: Dolniak, Blazej, Katsoulidis, Efstratios, Carayol, Nathalie, Altman, Jessica K., Redig, Amanda J., Tallman, Martin S., Ueda, Takeshi, Watanabe-Fukunaga, Rie, Fukunaga, Rikiro, Platanias, Leonidas C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2335346/
https://ncbi.nlm.nih.gov/pubmed/18299328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708816200
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