Retrograde movements determine effective stem cell numbers in the intestine

Morphology and functionality of the epithelial lining differ along the intestinal tract, yet tissue renewal at all sites is driven by stem cells at the base of crypts(1–3). Whether stem cell numbers and behaviour vary at different sites is unknown. Here, we show by intravital microscopy that despite...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I.J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J.A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodríguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614894/
https://ncbi.nlm.nih.gov/pubmed/35831497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-022-04962-0
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