Retrograde movements determine effective stem cell numbers in the intestine

Morphology and functionality of the epithelial lining differ along the intestinal tract, yet tissue renewal at all sites is driven by stem cells at the base of crypts(1–3). Whether stem cell numbers and behaviour vary at different sites is unknown. Here, we show by intravital microscopy that despite...

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Pubblicato in:Nature
Autori principali: Azkanaz, Maria, Corominas-Murtra, Bernat, Ellenbroek, Saskia I.J., Bruens, Lotte, Webb, Anna T., Laskaris, Dimitrios, Oost, Koen C., Lafirenze, Simona J.A., Annusver, Karl, Messal, Hendrik A., Iqbal, Sharif, Flanagan, Dustin J., Huels, David J., Rojas-Rodríguez, Felipe, Vizoso, Miguel, Kasper, Maria, Sansom, Owen J., Snippert, Hugo J., Liberali, Prisca, Simons, Benjamin D., Katajisto, Pekka, Hannezo, Edouard, van Rheenen, Jacco
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2022
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7614894/
https://ncbi.nlm.nih.gov/pubmed/35831497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-022-04962-0
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