How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials?

di Guantai, Eric, Chibale, Kelly
Pubblicazione 2011

Insights into Integrated Lead Generation and Target Identification in Malaria and Tuberculosis Drug Discovery

di Okombo, John, Chibale, Kelly
Pubblicato in Acc Chem Res (2017)

Recent updates in the discovery and development of novel antimalarial drug candidates

di Okombo, John, Chibale, Kelly
Pubblicato in Medchemcomm (2018)

Correction: Recent updates in the discovery and development of novel antimalarial drug candidates

di Okombo, John, Chibale, Kelly
Pubblicato in Medchemcomm (2018)

Strategies to Combat Multi-Drug Resistance in Tuberculosis

di Singh, Vinayak, Chibale, Kelly
Pubblicato in Acc Chem Res (2021)

Metallocene Antimalarials: The Continuing Quest

di Blackie, Margaret A. L., Chibale, Kelly
Pubblicazione 2008

The quest for the holy grail: new antitubercular chemical entities, targets and strategies

di Huszár, Stanislav, Chibale, Kelly, Singh, Vinayak
Pubblicato in Drug Discov Today (2020)

Novel tetracyclic structures from the synthesis of thiolactone-isatin hybrids

di Hans, Renate Hazel, Su, Hong, Chibale, Kelly
Pubblicazione 2010

Incorporation of an intramolecular hydrogen bonding motif in the side chain of antimalarial benzimidazoles

di Attram, Henrietta D., Wittlin, Sergio, Chibale, Kelly
Pubblicato in Medchemcomm (2019)

Drug discovery in Africa impacts of genomics, natural products, traditional medicines, insights into medicinal chemistry, and technology platforms in pursuit of new drugs /

di Chibale, Kelly, Davies-Coleman, Mike, Masimirembwa, Collen Mutowembwa
Pubblicazione c201

Identification of steroid-like natural products as antiplasmodial agents by 2D and 3D similarity-based virtual screening

di Pavadai, Elumalai, Kaur, Gurminder, Wittlin, Sergio, Chibale, Kelly
Pubblicato in Medchemcomm (2017)

Synthesis of 4-aminoquinoline–pyrimidine hybrids as potent antimalarials and their mode of action studies

di Singh, Kamaljit, Kaur, Hardeep, Chibale, Kelly, Balzarini, Jan
Pubblicato in Eur J Med Chem (2013)

Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles

di Tukulula, Matshawandile, Louw, Stefan, Njoroge, Mathew, Chibale, Kelly
Pubblicato in Molecules (2020)

The Role of Natural Products in Drug Discovery and Development against Neglected Tropical Diseases

di Cheuka, Peter Mubanga, Mayoka, Godfrey, Mutai, Peggoty, Chibale, Kelly
Pubblicato in Molecules (2016)

Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular...

di Dziwornu, Godwin Akpeko, Kamunya, Stephanie, Ntsabo, Tando, Chibale, Kelly
Pubblicato in Medchemcomm (2019)

Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine

di Njogu, Peter M., Gut, Jiri, Rosenthal, Philip J., Chibale, Kelly
Pubblicazione 2013

Chloroquine-containing compounds: a patent review (2010 – 2014)

di Njaria, Paul M, Okombo, John, Njuguna, Nicholas M, Chibale, Kelly
Pubblicato in Expert Opin Ther Pat (2015)

Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

di Dziwornu, Godwin Akpeko, Attram, Henrietta Dede, Gachuhi, Samuel, Chibale, Kelly
Pubblicato in RSC Med Chem (2020)

Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities

di Arendse, Lauren B., Wyllie, Susan, Chibale, Kelly, Gilbert, Ian H.
Pubblicato in ACS Infect Dis (2021)

Antiplasmodial imidazopyridazines: structure–activity relationship studies lead to the identification of analogues with improved solubility and hERG profiles

di Cheuka, Peter Mubanga, Lawrence, Nina, Taylor, Dale, Wittlin, Sergio, Chibale, Kelly
Pubblicato in Medchemcomm (2018)