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Incorporation of an intramolecular hydrogen bonding motif in the side chain of antimalarial benzimidazoles

Analogues of a novel class of benzimidazoles with an intramolecular hydrogen bonding motif have been synthesized and evaluated in vitro for their antiplasmodium activity against chloroquine-sensitive (NF54) and multi-drug resistant (K1) strains of the human malaria parasite Plasmodium falciparum. Co...

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Bibliographic Details
Published in:Medchemcomm
Main Authors: Attram, Henrietta D., Wittlin, Sergio, Chibale, Kelly
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6457172/
https://ncbi.nlm.nih.gov/pubmed/31015908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00608c
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