A carregar...
An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent
Background: The carboxylesterase Notum has been shown to act as a key negative regulator of the Wnt signalling pathway by mediating the depalmitoleoylation of Wnt proteins. LP-922056 (1) is an orally active inhibitor of Notum. We are investigating the role of Notum in modulating Wnt signalling in th...
Na minha lista:
| Publicado no: | Beilstein J Org Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Beilstein-Institut
2019
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6880826/ https://ncbi.nlm.nih.gov/pubmed/31807213 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.15.271 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|