Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT(2C) Receptor Agonists

[Image: see text] A series of pyrido[3,4-d]azepines that are potent and selective 5-HT(2C) receptor agonists is disclosed. Compound 7 (PF-04781340) is identified as a suitable lead owing to good 5-HT(2C) potency, selectivity over 5-HT(2B) agonism, and in vitro ADME properties commensurate with an or...

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Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Rouquet, Guy, Moore, Dianna E., Spain, Malcolm, Allwood, Daniel M., Battilocchio, Claudio, Blakemore, David C., Fish, Paul V., Jenkinson, Stephen, Jessiman, Alan S., Ley, Steven V., McMurray, Gordon, Storer, R. Ian
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2015
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4360148/
https://ncbi.nlm.nih.gov/pubmed/25815155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500507v
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