The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties

This study evaluated the in vitro and in vivo pharmacological properties of TD-8954, a potent and selective 5-HT(4) receptor agonist. TD-8954 had high affinity (pK(i) = 9.4) for human recombinant 5-HT(4(c)) (h5-HT(4(c))) receptors, and selectivity (>2,000-fold) over all other 5-hydroxytryptamine...

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Detalhes bibliográficos
Main Authors: Beattie, David T., Armstrong, Scott R., Vickery, Ross G., Tsuruda, Pamela R., Campbell, Christina B., Richardson, Carrie, McCullough, Julia L., Daniels, Oranee, Kersey, Kathryn, Li, Yu-Ping, Kim, Karl H. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108484/
https://ncbi.nlm.nih.gov/pubmed/21687517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2011.00025
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