Promoting Illiteracy in Epigenetics: An Emerging Therapeutic Strategy

Por Wigle, Tim J
Publicado em 2011

Directed Molecular Screening for RecA ATPase Inhibitors

Por Wigle, Tim J., Singleton, Scott F.
Publicado em 2007

A complementary pair of rapid molecular screening assays for RecA activities

Por Lee, Andrew M., Wigle, Tim J., Singleton, Scott F.
Publicado em 2007

Epigenetics: Tools and Technologies

Por Janzen, William P., Wigle, Tim J., Jin, Jian, Frye, Stephen V.
Publicado em 2010

Identification of non-peptide Malignant Brain Tumor (MBT) repeat antagonists by Virtual Screening of commercially available compounds

Por Kireev, Dmitri, Wigle, Tim J., Norris-Drouin, Jacqueline, Herold, J. Martin, Janzen, William P., Frye, Stephen V.
Publicado em 2010

Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis

Por Wigle, Tim J., Provencher, Laurel M., Norris, Jacqueline L., Jin, Jian, Brown, Peter J., Frye, Stephen V., Janzen, William P.
Publicado em 2010

Novel Inhibitors of E. coli RecA ATPase Activity

Por Sexton, Jonathan Z, Wigle, Tim J, He, Qingping, Hughes, Mark A, Smith, Ginger R, Singleton, Scott F, Williams, Alfred L, Yeh, Li-An
Publicado em 2010

Inhibitors of RecA Activity Discovered by High-Throughput Screening: Cell-Permeable Small Molecules Attenuate the SOS Response in Escherichia coli

Por Wigle, Tim J., Sexton, Jonathan Z., Gromova, Anna V., Hadimani, Mallinath B., Hughes, Mark A., Smith, Ginger R., Yeh, Li-An, Singleton, Scott F.
Publicado em 2009

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

Por Knutson, Sarah K., Warholic, Natalie M., Wigle, Tim J., Klaus, Christine R., Allain, Christina J., Raimondi, Alejandra, Porter Scott, Margaret, Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M., Kuntz, Kevin W., Keilhack, Heike
Publicado em 2013

Small Molecule Ligands of Methyl-Lysine Binding Proteins

Por Herold, J. Martin, Wigle, Tim J., Norris, Jacqueline L., Lam, Robert, Korboukh, Victoria K., Gao, Cen, Ingerman, Lindsey A., Kireev, Dmitri B., Senisterra, Guillermo, Vedadi, Masoud, Tripathy, Ashutosh, Brown, Peter J., Arrowsmith, Cheryl H., Jin, Jian, Janzen, William P., Frye, Stephen V.
Publicado em 2011

Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas

Por Knutson, Sarah K., Warholic, Natalie M., Johnston, L. Danielle, Klaus, Christine R., Wigle, Tim J., Iwanowicz, Dorothy, Littlefield, Bruce A., Porter-Scott, Margaret, Smith, Jesse J., Moyer, Mikel P., Copeland, Robert A., Pollock, Roy M., Kuntz, Kevin W., Raimondi, Alejandra, Keilhack, Heike
Publicado no PLoS One (2014)

Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound

Por Mitchell, Lorna H., Drew, Allison E., Ribich, Scott A., Rioux, Nathalie, Swinger, Kerren K., Jacques, Suzanne L., Lingaraj, Trupti, Boriack-Sjodin, P. Ann, Waters, Nigel J., Wigle, Tim J., Moradei, Oscar, Jin, Lei, Riera, Tom, Porter-Scott, Margaret, Moyer, Mikel P., Smith, Jesse J., Chesworth, Richard, Copeland, Robert A.
Publicado no ACS Med Chem Lett (2015)

EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

Por Campbell, John E., Kuntz, Kevin W., Knutson, Sarah K., Warholic, Natalie M., Keilhack, Heike, Wigle, Tim J., Raimondi, Alejandra, Klaus, Christine R., Rioux, Nathalie, Yokoi, Akira, Kawano, Satoshi, Minoshima, Yukinori, Choi, Hyeong-Wook, Porter Scott, Margaret, Waters, Nigel J., Smith, Jesse J., Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A.
Publicado no ACS Med Chem Lett (2015)

Protein Lysine Methyltransferase G9a Inhibitors: Design, Synthesis, and Structure Activity Relationships of 2,4-Diamino-7-aminoalkoxy-quinazolines.

Por Liu, Feng, Chen, Xin, Allali-Hassani, Abdellah, Quinn, Amy M., Wigle, Tim J., Wasney, Gregory A., Dong, Aiping, Senisterra, Guillermo, Chau, Irene, Siarheyeva, Alena, Norris, Jacqueline L., Kireev, Dmitri B., Jadhav, Ajit, Herold, J. Martin, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Brown, Peter J., Simeonov, Anton, Vedadi, Masoud, Jin, Jian
Publicado em 2010

Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor

Por Mitchell, Lorna H., Boriack-Sjodin, P. Ann, Smith, Sherri, Thomenius, Michael, Rioux, Nathalie, Munchhof, Michael, Mills, James E., Klaus, Christine, Totman, Jennifer, Riera, Thomas V., Raimondi, Alejandra, Jacques, Suzanne L., West, Kip, Foley, Megan, Waters, Nigel J., Kuntz, Kevin W., Wigle, Tim J., Scott, Margaret Porter, Copeland, Robert A., Smith, Jesse J., Chesworth, Richard
Publicado no ACS Med Chem Lett (2015)

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

Por Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Liu, Feng, Rival-Gervier, Sylvie, Allali-Hassani, Abdellah, Labrie, Viviane, Wigle, Tim J, Dimaggio, Peter A, Wasney, Gregory A, Siarheyeva, Alena, Dong, Aiping, Tempel, Wolfram, Wang, Sun-Chong, Chen, Xin, Chau, Irene, Mangano, Thomas J, Huang, Xi-ping, Simpson, Catherine D, Pattenden, Samantha G, Norris, Jacqueline L, Kireev, Dmitri B, Tripathy, Ashutosh, Edwards, Aled, Roth, Bryan L, Janzen, William P, Garcia, Benjamin A, Petronis, Arturas, Ellis, James, Brown, Peter J, Frye, Stephen V, Arrowsmith, Cheryl H, Jin, Jian
Publicado em 2011