Assessment of Free Energy Predictors for Ligand Binding to a Methyllysine Histone Code Reader

Por Gao, Cen, Herold, J. Martin, Kireev, Dmitri
Publicado em 2011

Accounting for Ligand Conformational Restriction in Calculations of Protein-Ligand Binding Affinities

Por Gao, Cen, Park, Min-Sun, Stern, Harry A.
Publicado em 2010

Targets in Epigenetics: Inhibiting the Methyl Writers of the Histone Code

Por Yost, Julianne M, Korboukh, Ilia, Liu, Feng, Gao, Cen, Jin, Jian
Publicado em 2011

Drug Discovery Toward Antagonists of Methyl-Lysine Binding Proteins

Por Herold, J. Martin, Ingerman, Lindsey A, Gao, Cen, Frye, Stephen V
Publicado em 2011

Biophysical probes reveal a “compromise” nature of the methyllysine binding pocket in L3MBTL1

Por Gao, Cen, Herold, J. Martin, Kireev, Dmitri, Wigle, Tim, Norris, Jacqueline L., Frye, Stephen
Publicado em 2011

Beyond PAINs: Chemotype Sensitivity of Protein Methyltransferases in Screens

Por Gao, Cen, Margolis, Brandon J., Strelow, John M., Vidler, Lewis R., Mader, Mary M.
Publicado no ACS Med Chem Lett (2015)

Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors

Por Liu, Feng, Li, Fengling, Ma, Anqi, Dobrovetsky, Elena, Dong, Aiping, Gao, Cen, Korboukh, Ilia, Liu, Jing, Smil, David, Brown, Peter J., Frye, Stephen V., Arrowsmith, Cheryl H., Schapira, Matthieu, Vedadi, Masoud, Jin, Jian
Publicado no J Med Chem (2013)

Small Molecule Ligands of Methyl-Lysine Binding Proteins

Por Herold, J. Martin, Wigle, Tim J., Norris, Jacqueline L., Lam, Robert, Korboukh, Victoria K., Gao, Cen, Ingerman, Lindsey A., Kireev, Dmitri B., Senisterra, Guillermo, Vedadi, Masoud, Tripathy, Ashutosh, Brown, Peter J., Arrowsmith, Cheryl H., Jin, Jian, Janzen, William P., Frye, Stephen V.
Publicado em 2011

Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain

Por James, Lindsey I., Barsyte-Lovejoy, Dalia, Zhong, Nan, Krichevsky, Liubov, Korboukh, Victoria K., Herold, Martin J., MacNevin, Christopher J., Norris, Jacqueline L., Sagum, Cari A., Tempel, Wolfram, Marcon, Edyta, Guo, Hongbo, Gao, Cen, Huang, Xi-Ping, Duan, Shili, Emili, Andrew, Greenblatt, Jack F., Kireev, Dmitri B., Jin, Jian, Janzen, William P., Brown, Peter J., Bedford, Mark T., Arrowsmith, Cheryl H., Frye, Stephen V.
Publicado em 2013

An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1

Por Konze, Kyle D., Ma, Anqi, Li, Fengling, Barsyte-Lovejoy, Dalia, Parton, Trevor, MacNevin°, Christopher J., Liu, Feng, Gao, Cen, Huang, Xi-Ping, Kuznetsova, Ekaterina, Rougie°, Marie, Jiang, Alice, Pattenden, Samantha G., Norris, Jacqueline L., James, Lindsey I., Roth, Bryan L., Brown, Peter J., Frye, Stephen V., Arrowsmith, Cheryl H., Hahn°, Klaus M., Wang, Gang Greg, Vedadi, Masoud, Jin, Jian
Publicado em 2013