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Assessment of Free Energy Predictors for Ligand Binding to a Methyllysine Histone Code Reader

Methyllysine histone code readers constitute a new promising group of potential drug targets. For instance, L3MBTL1, a Malignant Brain Tumor (MBT) protein, selectively binds mono- and di-methyllysine epigenetic marks (KMe, KMe(2)) that eventually results in the negative regulation of multiple genes...

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Détails bibliographiques
Auteurs principaux: Gao, Cen, Herold, J. Martin, Kireev, Dmitri
Format: Artigo
Langue:Inglês
Publié: 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276689/
https://ncbi.nlm.nih.gov/pubmed/22183769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.22888
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