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Assessment of Free Energy Predictors for Ligand Binding to a Methyllysine Histone Code Reader
Methyllysine histone code readers constitute a new promising group of potential drug targets. For instance, L3MBTL1, a Malignant Brain Tumor (MBT) protein, selectively binds mono- and di-methyllysine epigenetic marks (KMe, KMe(2)) that eventually results in the negative regulation of multiple genes...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276689/ https://ncbi.nlm.nih.gov/pubmed/22183769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcc.22888 |
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