Novel Therapeutics Targeting Epigenetics: New Molecules, New Methods

Por Frye, Stephen V., Jin, Jian
Publicado no ACS Med Chem Lett (2016)

Writing and Rewriting the Epigenetic Code of Cancer Cells: From Engineered Proteins to Small Molecules

Por Blancafort, Pilar, Jin, Jian, Frye, Stephen
Publicado em 2013

CHEMICAL GENETIC AND EPIGENETICS: Chemical probes for methyl lysine reader domains

Por James, Lindsey I., Frye, Stephen V.
Publicado no Curr Opin Chem Biol (2016)

Target class drug discovery

Por Barnash, Kimberly D, James, Lindsey I, Frye, Stephen V
Publicado no Nat Chem Biol (2017)

Epigenetics: Tools and Technologies

Por Janzen, William P., Wigle, Tim J., Jin, Jian, Frye, Stephen V.
Publicado em 2010

Drug Discovery Toward Antagonists of Methyl-Lysine Binding Proteins

Por Herold, J. Martin, Ingerman, Lindsey A, Gao, Cen, Frye, Stephen V
Publicado em 2011

Bringing together the academic drug discovery community

Por Slusher, Barbara S., Conn, P. Jeffrey, Frye, Stephen, Glicksman, Marcie, Arkin, Michelle
Publicado em 2013

ACADEMIC DRUG DISCOVERY IN THE US: A SURVEY AND ANALYSIS

Por Frye, Stephen V., Crosby, Marina D., Edwards, Teresa P., Juliano, Rudolph L.
Publicado no Nat Rev Drug Discov (2011)

Biophysical probes reveal a “compromise” nature of the methyllysine binding pocket in L3MBTL1

Por Gao, Cen, Herold, J. Martin, Kireev, Dmitri, Wigle, Tim, Norris, Jacqueline L., Frye, Stephen
Publicado em 2011

Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay

Por Foley, Caroline A., Potjewyd, Frances, Lamb, Kelsey N., James, Lindsey I., Frye, Stephen V.
Publicado no ACS Chem Biol (2019)

The L3MBTL3 methyl-lysine reader domain functions as a dimer

Por Baughman, Brandi M., Pattenden, Samantha G., Norris, Jacqueline L., James, Lindsey I., Frye, Stephen V.
Publicado no ACS Chem Biol (2015)

Retraction of “The L3MBTL3 Methyl-Lysine Reader Domain Functions As a Dimer”

Por Baughman, Brandi M., Pattenden, Samantha G., Norris, Jacqueline L., James, Lindsey I., Frye, Stephen V.
Publicado no ACS Chem Biol (2017)

Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency

Por Hopcraft, Sharon E., Pattenden, Samantha G., James, Lindsey I., Frye, Stephen, Dittmer, Dirk P., Damania, Blossom
Publicado no PLoS Pathog (2018)

Identification of non-peptide Malignant Brain Tumor (MBT) repeat antagonists by Virtual Screening of commercially available compounds

Por Kireev, Dmitri, Wigle, Tim J., Norris-Drouin, Jacqueline, Herold, J. Martin, Janzen, William P., Frye, Stephen V.
Publicado em 2010

Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis

Por Wigle, Tim J., Provencher, Laurel M., Norris, Jacqueline L., Jin, Jian, Brown, Peter J., Frye, Stephen V., Janzen, William P.
Publicado em 2010

AMP Is an Adenosine A(1) Receptor Agonist

Por Rittiner, Joseph E., Korboukh, Ilia, Hull-Ryde, Emily A., Jin, Jian, Janzen, William P., Frye, Stephen V., Zylka, Mark J.
Publicado em 2012

Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds

Por Zhou, Hao, Che, Xin, Bao, Guochen, Wang, Na, Peng, Li, Barnash, Kimberly D., Frye, Stephen V., James, Lindsey I., Bai, Xu
Publicado no Bioorg Med Chem Lett (2016)

A General TR-FRET Assay Platform for High-Throughput Screening and Characterizing Inhibitors of Methyl-Lysine Reader Proteins

Por Rectenwald, Justin M., Hardy, P. Brian, Norris-Drouin, Jacqueline L., Cholensky, Stephanie, James, Lindsey I., Frye, Stephen V., Pearce, Kenneth H.
Publicado no SLAS Discov (2019)

A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

Por Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Publicado no PLoS One (2016)

Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors

Por Baughman, Brandi M., Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A., Jessen, Henning J., Pearce, Kenneth H., Frye, Stephen V., Shears, Stephen B.
Publicado no PLoS One (2017)