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Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis

The discovery of small molecules targeting the > 80 enzymes that add (methyltransferases) or remove (demethylases) methyl marks from lysine and arginine residues, most notably present in histone tails, may yield unprecedented chemotherapeutic agents and facilitate regenerative medicine. To better...

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Bibliografiska uppgifter
Huvudupphovsmän: Wigle, Tim J., Provencher, Laurel M., Norris, Jacqueline L., Jin, Jian, Brown, Peter J., Frye, Stephen V., Janzen, William P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914686/
https://ncbi.nlm.nih.gov/pubmed/20659682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2010.04.014
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