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Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds
Epigenetic alterations relate to various human diseases, and developing inhibitors of Kme regulatory proteins is considered to be a new frontier for drug discovery. We were inspired by the known multicyclic ligands, UNC669 and UNC926, which are the first reported small molecule ligands for a methyl-...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4996710/ https://ncbi.nlm.nih.gov/pubmed/27528434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.08.004 |
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