Inhibition of SET Domain–Containing Lysine Methyltransferase 7/9 Ameliorates Renal Fibrosis

TGF-β1 activity results in methylation of lysine 4 of histone H3 (H3K4) through SET domain–containing lysine methyltransferase 7/9 (SET7/9) induction, which is important for the transcriptional activation of fibrotic genes in vitro. However, in vivo studies utilizing an experimental model of renal f...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Sasaki, Kensuke, Doi, Shigehiro, Nakashima, Ayumu, Irifuku, Taisuke, Yamada, Kyoko, Kokoroishi, Keiko, Ueno, Toshinori, Doi, Toshiki, Hida, Eisuke, Arihiro, Koji, Kohno, Nobuoki, Masaki, Takao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696564/
https://ncbi.nlm.nih.gov/pubmed/26045091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014090850
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