microRNA-200c regulates KLOTHO expression in human kidney cells under oxidative stress

KLOTHO deficiency is associated with the progression of kidney dysfunction, whereas its overexpression exerts renoprotective effects. Oxidative stress suppresses KLOTHO expression in renal epithelial cells but upregulates microRNA-200c (miR-200c) in human umbilical vein endothelial cells. In this st...

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Veröffentlicht in:PLoS One
Hauptverfasser: Morii, Kenichi, Yamasaki, Satoshi, Doi, Shigehiro, Irifuku, Taisuke, Sasaki, Kensuke, Doi, Toshiki, Nakashima, Ayumu, Arihiro, Koji, Masaki, Takao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568409/
https://ncbi.nlm.nih.gov/pubmed/31199854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0218468
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