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Inhibition of H3K9 methyltransferase G9a ameliorates methylglyoxal-induced peritoneal fibrosis

Activity of H3K9 histone methyltransferase G9a is reportedly induced by transforming growth factor-β1 (TGF-β1) and plays an important role in the progression of cancer and fibrosis. In this study, we investigated whether inhibition of G9a-mediated H3K9 methylation attenuates peritoneal fibrosis in m...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Maeda, Kazuya, Doi, Shigehiro, Nakashima, Ayumu, Nagai, Takuo, Irifuku, Taisuke, Ueno, Toshinori, Masaki, Takao
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5344517/
https://ncbi.nlm.nih.gov/pubmed/28278257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173706
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