Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase

SMYD3 is a SET domain-containing N-lysine methyltransferase associated with multiple cancers. Its reported substrates include histones (H3K4 and H4K5), vascular endothelial growth factor receptor 1 (VEGFR1 Lys(831)) and MAP3 kinase kinase (MAP3K2 Lys(260)). To reveal the structural basis for substra...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fu, Weiqi, Liu, Nan, Qiao, Qi, Wang, Mingzhu, Min, Jinrong, Zhu, Bing, Xu, Rui-Ming, Yang, Na
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4861483/
https://ncbi.nlm.nih.gov/pubmed/26929412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.709832
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