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Exploration of the Substrate Preference of Lysine Methyltransferase SMYD3 by Molecular Dynamics Simulations

[Image: see text] SMYD3, a SET and MYND domain containing lysine methyltransferase, catalyzes the transfer of the methyl group from a methyl donor onto the Nε group of a lysine residue in the substrate protein. Methylation of MAP3 kinase kinase (MAP3K2) by SMYD3 has been implicated in Ras-driven tum...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Sun, Jixue, Shi, Fandi, Yang, Na
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881823/
https://ncbi.nlm.nih.gov/pubmed/31788587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b01842
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