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Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non‐Histone Substrates

The SMYD2 protein lysine methyltransferase methylates various histone and non‐histone proteins and is overexpressed in several cancers. Using peptide arrays, we investigated the substrate specificity of the enzyme, revealing a recognition of leucine (or weaker phenylalanine) at the −1 peptide site a...

詳細記述

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書誌詳細
出版年:Chembiochem
主要な著者: Weirich, Sara, Schuhmacher, Maren Kirstin, Kudithipudi, Srikanth, Lungu, Cristiana, Ferguson, Andrew D., Jeltsch, Albert
フォーマット: Artigo
言語:Inglês
出版事項: John Wiley and Sons Inc. 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003753/
https://ncbi.nlm.nih.gov/pubmed/31612581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900582
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