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Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non‐Histone Substrates

The SMYD2 protein lysine methyltransferase methylates various histone and non‐histone proteins and is overexpressed in several cancers. Using peptide arrays, we investigated the substrate specificity of the enzyme, revealing a recognition of leucine (or weaker phenylalanine) at the −1 peptide site a...

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Dettagli Bibliografici
Pubblicato in:Chembiochem
Autori principali: Weirich, Sara, Schuhmacher, Maren Kirstin, Kudithipudi, Srikanth, Lungu, Cristiana, Ferguson, Andrew D., Jeltsch, Albert
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003753/
https://ncbi.nlm.nih.gov/pubmed/31612581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900582
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