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Analysis of the Substrate Specificity of the SMYD2 Protein Lysine Methyltransferase and Discovery of Novel Non‐Histone Substrates

The SMYD2 protein lysine methyltransferase methylates various histone and non‐histone proteins and is overexpressed in several cancers. Using peptide arrays, we investigated the substrate specificity of the enzyme, revealing a recognition of leucine (or weaker phenylalanine) at the −1 peptide site a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chembiochem
Egile Nagusiak: Weirich, Sara, Schuhmacher, Maren Kirstin, Kudithipudi, Srikanth, Lungu, Cristiana, Ferguson, Andrew D., Jeltsch, Albert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2019
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7003753/
https://ncbi.nlm.nih.gov/pubmed/31612581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900582
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