Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase

SMYD3 is a multifunctional epigenetic enzyme with lysine methyltransferase activity and various interaction partners. It is implicated in the pathophysiology of cancers but with an unclear mechanism. To discover tool compounds for clarifying its biochemistry and potential as a therapeutic target, a...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Chembiochem
Auteurs principaux: Talibov, Vladimir O., Fabini, Edoardo, FitzGerald, Edward A., Tedesco, Daniele, Cederfeldt, Daniela, Talu, Martin J., Rachman, Moira M., Mihalic, Filip, Manoni, Elisabetta, Naldi, Marina, Sanese, Paola, Forte, Giovanna, Lepore Signorile, Martina, Barril, Xavier, Simone, Cristiano, Bartolini, Manuela, Dobritzsch, Doreen, Del Rio, Alberto, Danielson, U. Helena
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2021
Sujets:
Full Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8248052/
https://ncbi.nlm.nih.gov/pubmed/33400854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000736
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires