APC Splicing Mutations Leading to In-Frame Exon 12 or Exon 13 Skipping Are Rare Events in FAP Pathogenesis and Define the Clinical Outcome

Familial adenomatous polyposis (FAP) is caused by germline mutations in the tumor suppressor gene APC. To date, nearly 2000 APC mutations have been described in FAP, most of which are predicted to result in truncated protein products. Mutations leading to aberrant APC splicing have rarely been repor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Genes (Basel)
Main Authors: Disciglio, Vittoria, Forte, Giovanna, Fasano, Candida, Sanese, Paola, Lepore Signorile, Martina, De Marco, Katia, Grossi, Valentina, Cariola, Filomena, Simone, Cristiano
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7997234/
https://ncbi.nlm.nih.gov/pubmed/33670833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes12030353
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados