Initial Testing (Stage 1) of Tazemetostat (EPZ-6438), a Novel EZH2 Inhibitor, by the Pediatric Preclinical Testing Program

by Kurmasheva, Raushan T., Sammons, Melissa, Favours, Edward, Wu, Jianwrong, Kurmashev, Dias, Cosmopoulos, Katherine, Keilhack, Heike, Klaus, Christine R., Houghton, Peter J., Smith, Malcolm A.
Published in Pediatr Blood Cancer (2016)

Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2

by Knutson, Sarah K., Warholic, Natalie M., Wigle, Tim J., Klaus, Christine R., Allain, Christina J., Raimondi, Alejandra, Porter Scott, Margaret, Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M., Kuntz, Kevin W., Keilhack, Heike
Published 2013

Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas

by Knutson, Sarah K., Warholic, Natalie M., Johnston, L. Danielle, Klaus, Christine R., Wigle, Tim J., Iwanowicz, Dorothy, Littlefield, Bruce A., Porter-Scott, Margaret, Smith, Jesse J., Moyer, Mikel P., Copeland, Robert A., Pollock, Roy M., Kuntz, Kevin W., Raimondi, Alejandra, Keilhack, Heike
Published in PLoS One (2014)

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia

by Daigle, Scott R., Olhava, Edward J., Therkelsen, Carly A., Basavapathruni, Aravind, Jin, Lei, Boriack-Sjodin, P. Ann, Allain, Christina J., Klaus, Christine R., Raimondi, Alejandra, Scott, Margaret Porter, Waters, Nigel J., Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A., Richon, Victoria M., Pollock, Roy M.
Published 2013

EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

by Campbell, John E., Kuntz, Kevin W., Knutson, Sarah K., Warholic, Natalie M., Keilhack, Heike, Wigle, Tim J., Raimondi, Alejandra, Klaus, Christine R., Rioux, Nathalie, Yokoi, Akira, Kawano, Satoshi, Minoshima, Yukinori, Choi, Hyeong-Wook, Porter Scott, Margaret, Waters, Nigel J., Smith, Jesse J., Chesworth, Richard, Moyer, Mikel P., Copeland, Robert A.
Published in ACS Med Chem Lett (2015)