A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is essential for maturation of ribosomes, may have a role in lipogenesis, and is implicated in several diseases. A potent, selective, and cell- active PRMT3 inhibitor would be a valuable tool for further invest...

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Publicado no:Angew Chem Int Ed Engl
Main Authors: Kaniskan, H. Ümit, Szewczyk, Magdalena M., Yu, Zhengtian, Eram, Mohammad S., Yang, Xiaobao, Schmidt, Keith, Luo, Xiao, Dai, Miao, He, Feng, Zang, Irene, Lin, Ying, Kennedy, Steven, Li, Fengling, Dobrovetsky, Elena, Dong, Aiping, Smil, David, Min, Sun-Joon, Landon, Melissa, Lin-Jones, Jennifer, Huang, Xi-Ping, Roth, Bryan L., Schapira, Matthieu, Atadja, Peter, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Brown, Peter J., Zhao, Kehao, Jin, Jian, Vedadi, Masoud
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400258/
https://ncbi.nlm.nih.gov/pubmed/25728001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201412154
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