Discovery of selective activators of PRC2 mutant EED-I363M

Many common disease-causing mutations result in loss-of-function (LOF) of the proteins in which they occur. LOF mutations have proven recalcitrant to pharmacologic intervention, presenting a challenge for the development of targeted therapeutics. Polycomb repressive complex 2 (PRC2), which contains...

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Publicado no:Sci Rep
Main Authors: Suh, Junghyun L., Barnash, Kimberly D., Abramyan, Tigran M., Li, Fengling, The, Juliana, Engelberg, Isabelle A., Vedadi, Masoud, Brown, Peter J., Kireev, Dmitri B., Arrowsmith, Cheryl H., James, Lindsey I., Frye, Stephen V.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484020/
https://ncbi.nlm.nih.gov/pubmed/31024026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43005-z
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