Discovery of selective activators of PRC2 mutant EED-I363M

Many common disease-causing mutations result in loss-of-function (LOF) of the proteins in which they occur. LOF mutations have proven recalcitrant to pharmacologic intervention, presenting a challenge for the development of targeted therapeutics. Polycomb repressive complex 2 (PRC2), which contains...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Suh, Junghyun L., Barnash, Kimberly D., Abramyan, Tigran M., Li, Fengling, The, Juliana, Engelberg, Isabelle A., Vedadi, Masoud, Brown, Peter J., Kireev, Dmitri B., Arrowsmith, Cheryl H., James, Lindsey I., Frye, Stephen V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6484020/
https://ncbi.nlm.nih.gov/pubmed/31024026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43005-z
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