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Structure-Functional Selectivity Relationship Studies of β-arrestin-biased Dopamine D(2) Receptor Agonists

Functionally selective G protein-coupled receptor (GPCR) ligands, which differentially modulate canonical and non-canonical signaling, are extremely useful for elucidating key signal transduction pathways essential for both the therapeutic actions and side-effects of drugs. However, few such ligands...

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Detalhes bibliográficos
Main Authors: Chen, Xin, Sassano, Maria F., Zheng, Lianyou, Setola, Vincent, Chen, Meng, Bai, Xu, Frye, Stephen V., Wetsel, William C., Roth, Bryan L., Jin, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443605/
https://ncbi.nlm.nih.gov/pubmed/22845053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300603y
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