Discovery of β-Arrestin–Biased Dopamine D(2) Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

Elucidating the key signal transduction pathways essential for both antipsychotic efficacy and side-effect profiles is essential for developing safer and more effective therapies. Recent work has highlighted noncanonical modes of dopamine D(2) receptor (D(2)R) signaling via β-arrestins as being impo...

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Hauptverfasser: Allen, John A., Yost, Julianne M., Setola, Vincent, Chen, Xin, Sassano, Maria F., Chen, Meng, Peterson, Sean, Yadav, Prem N., Huang, Xi-ping, Feng, Bo, Jensen, Niels H., Che, Xin, Bai, Xu, Frye, Stephen V., Wetsel, William C., Caron, Marc G., Javitch, Jonathan A., Roth, Bryan L., Jin, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215024/
https://ncbi.nlm.nih.gov/pubmed/22025698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104807108
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