Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice

Current antipsychotic drugs (APDs) show efficacy with positive symptoms, but are limited in treating negative or cognitive features of schizophrenia. Whereas all currently FDA-approved medications target primarily the dopamine D2 receptor (D2R) to inhibit G(i/o)-mediated adenylyl cyclase, a recent s...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Park, Su M, Chen, Meng, Schmerberg, Claire M, Dulman, Russell S, Rodriguiz, Ramona M, Caron, Marc G, Jin, Jian, Wetsel, William C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4707817/
https://ncbi.nlm.nih.gov/pubmed/26129680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.196
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