Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

The current dopamine (DA) hypothesis of schizophrenia postulates striatal hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 receptors (D2Rs), like aripiprazole, were developed to simultaneously target both phenomena, they do not effectively improve cortical dysfunct...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Urs, Nikhil M., Gee, Steven M., Pack, Thomas F., McCorvy, John D., Evron, Tama, Snyder, Joshua C., Yang, Xiaobao, Rodriguiz, Ramona M., Borrelli, Emiliana, Wetsel, William C., Jin, Jian, Roth, Bryan L., O’Donnell, Patricio, Caron, Marc G.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167191/
https://ncbi.nlm.nih.gov/pubmed/27911814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614347113
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