Distinct cortical and striatal actions of a β-arrestin–biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties

The current dopamine (DA) hypothesis of schizophrenia postulates striatal hyperdopaminergia and cortical hypodopaminergia. Although partial agonists at DA D2 receptors (D2Rs), like aripiprazole, were developed to simultaneously target both phenomena, they do not effectively improve cortical dysfunct...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Urs, Nikhil M., Gee, Steven M., Pack, Thomas F., McCorvy, John D., Evron, Tama, Snyder, Joshua C., Yang, Xiaobao, Rodriguiz, Ramona M., Borrelli, Emiliana, Wetsel, William C., Jin, Jian, Roth, Bryan L., O’Donnell, Patricio, Caron, Marc G.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2016
Subjects:
PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167191/
https://ncbi.nlm.nih.gov/pubmed/27911814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614347113
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items