Structure and Function of Serotonin G protein Coupled Receptors

অনুযায়ী McCorvy, John D., Roth, Bryan L.
প্রকাশিত Pharmacol Ther (2015)

A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference

অনুযায়ী McCorvy, John D., Harland, Aubrie A., Maglathlin, Rebecca, Nichols, David E.
প্রকাশিত 2011

Assessment of dopamine D(1) receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393

অনুযায়ী Clark, Alia H., McCorvy, John D., Watts, Val J., Nichols, David E.
প্রকাশিত 2011

Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation

অনুযায়ী Hoehn, Ross D., Nichols, David E., McCorvy, John D., Neven, Hartmut, Kais, Sabre
প্রকাশিত Proc Natl Acad Sci U S A (2017)

Design of Fluorinated Cyclopropane Derivatives of 2-Phenylcyclopropylmethylamine Leading to Identification of a Selective Serotonin 2C (5-HT(2C)) Receptor Agonist without 5-HT(2B)...

অনুযায়ী Zhang, Guiping, McCorvy, John D., Shen, Sida, Cheng, Jianjun, Roth, Bryan L., Kozikowski, Alan P.
প্রকাশিত Eur J Med Chem (2019)

trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family

অনুযায়ী Pigott, Adam, Frescas, Stewart, McCorvy, John D, Huang, Xi-Ping, Roth, Bryan L, Nichols, David E
প্রকাশিত 2012

Discovery of G Protein-biased D2 Dopamine Receptor Partial Agonists

অনুযায়ী Chen, Xin, McCorvy, John D., Fischer, Matthew G., Butler, Kyle V., Shen, Yudao, Roth, Bryan L., Jin, Jian
প্রকাশিত J Med Chem (2016)

A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

অনুযায়ী Chan, John D., McCorvy, John D., Acharya, Sreemoyee, Johns, Malcolm E., Day, Timothy A., Roth, Bryan L., Marchant, Jonathan S.
প্রকাশিত PLoS Pathog (2016)

Discovery of N-Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT(2C)) Receptor Agonists for Potential Use as Antipsychotic Medications

অনুযায়ী Zhang, Guiping, Cheng, Jianjun, McCorvy, John D., Lorello, Paul J., Caldarone, Barbara J., Roth, Bryan L., Kozikowski, Alan P.
প্রকাশিত J Med Chem (2017)

Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D(3) receptor-selective full agonist ligand

অনুযায়ী Clark, Alia H., McCorvy, John D., Conley, Jason M., Williams, Whitney K., Bekkam, Markondaiah, Watts, Val J., Nichols, David E.
প্রকাশিত 2012

Structure-based discovery of potent and selective melatonin receptor agonists

অনুযায়ী Patel, Nilkanth, Huang, Xi Ping, Grandner, Jessica M, Johansson, Linda C, Stauch, Benjamin, McCorvy, John D, Liu, Yongfeng, Roth, Bryan, Katritch, Vsevolod
প্রকাশিত eLife (2020)

The chemokine X-factor: Structure-function analysis of the CXC motif at CXCR4 and ACKR3

অনুযায়ী Wedemeyer, Michael J., Mahn, Sarah A., Getschman, Anthony E., Crawford, Kyler S., Peterson, Francis C., Marchese, Adriano, McCorvy, John D., Volkman, Brian F.
প্রকাশিত J Biol Chem (2020)

Investigation of the Structure–Activity Relationships of Psilocybin Analogues

অনুযায়ী Klein, Adam K., Chatha, Muhammad, Laskowski, Lauren J., Anderson, Emilie I., Brandt, Simon D., Chapman, Stephen J., McCorvy, John D., Halberstadt, Adam L.
প্রকাশিত ACS Pharmacol Transl Sci (2020)

Extensive Rigid Analogue Design Maps the Binding Conformation of Potent N-Benzylphenethylamine 5-HT(2A) Serotonin Receptor Agonist Ligands

অনুযায়ী Juncosa, Jose I., Hansen, Martin, Bonner, Lisa A., Cueva, Juan Pablo, Maglathlin, Rebecca, McCorvy, John D., Marona-Lewicka, Danuta, Lill, Markus A., Nichols, David E.
প্রকাশিত 2012

Designing Functionally Selective Noncatechol Dopamine D(1) Receptor Agonists with Potent In Vivo Antiparkinsonian Activity

অনুযায়ী Martini, Michael L., Ray, Caroline, Yu, Xufen, Liu, Jing, Pogorelov, Vladimir M., Wetsel, William C., Huang, Xi-Ping, McCorvy, John D., Caron, Marc G., Jin, Jian
প্রকাশিত ACS Chem Neurosci (2019)

Comparison of the enantiomers of (±)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic rece...

অনুযায়ী Przybyla, Julie A., Cueva, Juan P., Chemel, Benjamin R., Joseph Hsu, K., Riese, David J., McCorvy, John D., Chester, Julia A., Nichols, David E., Watts, Val J.
প্রকাশিত 2008

Structural Determinants of 5-HT(2B) Receptor Activation and Biased Agonism

অনুযায়ী McCorvy, John D., Wacker, Daniel, Wang, Sheng, Agegnehu, Bemnat, Liu, Jing, Lansu, Katherine, Tribo, Alexandra R., Olsen, Reid H.J., Che, Tao, Jin, Jian, Roth, Bryan L.
প্রকাশিত Nat Struct Mol Biol (2018)

D(2) Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine

অনুযায়ী Shen, Yudao, McCorvy, John D., Martini, Michael L., Rodriguiz, Ramona M., Pogorelov, Vladimir M., Ward, Karen M., Wetsel, William C., Liu, Jing, Roth, Bryan L., Jin, Jian
প্রকাশিত J Med Chem (2019)

Defining Structure−Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D(1) Receptor Agonists

অনুযায়ী Martini, Michael L., Liu, Jing, Ray, Caroline, Yu, Xufen, Huang, Xi-Ping, Urs, Aarti, Urs, Nikhil, McCorvy, John D., Caron, Marc G., Roth, Bryan L., Jin, Jian
প্রকাশিত J Med Chem (2019)

Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

অনুযায়ী McCorvy, John D., Butler, Kyle V., Kelly, Brendan, Rechsteiner, Katie, Karpiak, Joel, Betz, Robin M., Kormos, Bethany L., Shoichet, Brian K., Dror, Ron O., Jin, Jian, Roth, Bryan L.
প্রকাশিত Nat Chem Biol (2017)