Structure-based discovery of potent and selective melatonin receptor agonists

Melatonin receptors MT(1) and MT(2) are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new ligand chemotypes using recently solved high-resol...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Patel, Nilkanth, Huang, Xi Ping, Grandner, Jessica M, Johansson, Linda C, Stauch, Benjamin, McCorvy, John D, Liu, Yongfeng, Roth, Bryan, Katritch, Vsevolod
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2020
Gaiak:
Biochemistry and Chemical Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080406/
https://ncbi.nlm.nih.gov/pubmed/32118583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53779
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