Structure-based discovery of potent and selective melatonin receptor agonists

Melatonin receptors MT(1) and MT(2) are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new ligand chemotypes using recently solved high-resol...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Patel, Nilkanth, Huang, Xi Ping, Grandner, Jessica M, Johansson, Linda C, Stauch, Benjamin, McCorvy, John D, Liu, Yongfeng, Roth, Bryan, Katritch, Vsevolod
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2020
Ämnen:
Biochemistry and Chemical Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7080406/
https://ncbi.nlm.nih.gov/pubmed/32118583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53779
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