XFEL structures of the human MT(2) melatonin receptor reveal basis of subtype selectivity

The human MT(1)(1) and MT(2)(2) melatonin receptors are G protein-coupled receptors (GPCRs) involved in the regulation of circadian rhythm and sleep patterns(3). Drug development efforts target both receptors for treatment of insomnia, circadian rhythm and mood disorders, and cancer(3), while MT(2)...

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Detaylı Bibliyografya
Yayımlandı:Nature
Asıl Yazarlar: Johansson, Linda C., Stauch, Benjamin, McCorvy, John D., Han, Gye Won, Patel, Nilkanth, Huang, Xi-Ping, Batyuk, Alexander, Gati, Cornelius, Slocum, Samuel T., Li, Chufeng, Grandner, Jessica M., Hao, Shuming, Olsen, Reid H.J., Tribo, Alexandra R., Zaare, Sahba, Zhu, Lan, Zatsepin, Nadia A., Weierstall, Uwe, Yous, Saïd, Stevens, Raymond C., Liu, Wei, Roth, Bryan L., Katritch, Vsevolod, Cherezov, Vadim
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589158/
https://ncbi.nlm.nih.gov/pubmed/31019305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1144-0
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