XFEL structures of the human MT(2) melatonin receptor reveal basis of subtype selectivity

The human MT(1)(1) and MT(2)(2) melatonin receptors are G protein-coupled receptors (GPCRs) involved in the regulation of circadian rhythm and sleep patterns(3). Drug development efforts target both receptors for treatment of insomnia, circadian rhythm and mood disorders, and cancer(3), while MT(2)...

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Vydáno v:Nature
Hlavní autoři: Johansson, Linda C., Stauch, Benjamin, McCorvy, John D., Han, Gye Won, Patel, Nilkanth, Huang, Xi-Ping, Batyuk, Alexander, Gati, Cornelius, Slocum, Samuel T., Li, Chufeng, Grandner, Jessica M., Hao, Shuming, Olsen, Reid H.J., Tribo, Alexandra R., Zaare, Sahba, Zhu, Lan, Zatsepin, Nadia A., Weierstall, Uwe, Yous, Saïd, Stevens, Raymond C., Liu, Wei, Roth, Bryan L., Katritch, Vsevolod, Cherezov, Vadim
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589158/
https://ncbi.nlm.nih.gov/pubmed/31019305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1144-0
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