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Discovery of N-Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT(2C)) Receptor Agonists for Potential Use as Antipsychotic Medications
A series of N-substituted 2-phenylcyclopropylmethylamines were designed and synthesized, with the aim of finding 5-HT(2C)-selective agonists with preference for G(q) signaling. A number of these compounds exhibit 5-HT(2C) selectivity with preference for G(q)-mediated signaling compared with β-arrest...
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| Publicado no: | J Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7374938/ https://ncbi.nlm.nih.gov/pubmed/28657744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00584 |
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