Discovery of N-Substituted 2-Phenylcyclopropylmethylamines as Functionally Selective Serotonin 2C (5-HT(2C)) Receptor Agonists for Potential Use as Antipsychotic Medications

A series of N-substituted 2-phenylcyclopropylmethylamines were designed and synthesized, with the aim of finding 5-HT(2C)-selective agonists with preference for G(q) signaling. A number of these compounds exhibit 5-HT(2C) selectivity with preference for G(q)-mediated signaling compared with β-arrest...

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Publicado en:J Med Chem
Autores principales: Zhang, Guiping, Cheng, Jianjun, McCorvy, John D., Lorello, Paul J., Caldarone, Barbara J., Roth, Bryan L., Kozikowski, Alan P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7374938/
https://ncbi.nlm.nih.gov/pubmed/28657744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00584
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