Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents

The discovery of a new series of compounds that are potent, selective 5-HT(2C) receptor agonists is described herein as we continue our efforts to optimize the 2-phenylcyclopropylmethylamine scaffold. Modifications focused on the alkoxyl substituent present on the aromatic ring led to the identifica...

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Опубликовано в: :J Med Chem
Главные авторы: Cheng, Jianjun, Giguère, Patrick M., Onajole, Oluseye K., Lv, Wei, Gaisin, Arsen, Gunosewoyo, Hendra, Schmerberg, Claire M., Pogorelov, Vladimir M., Rodriguiz, Ramona M., Vistoli, Giulio, Wetsel, William C., Roth, Bryan L., Kozikowski, Alan P.
Формат: Artigo
Язык:Inglês
Опубликовано: 2015
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834193/
https://ncbi.nlm.nih.gov/pubmed/25633969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5019274
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