Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents

The discovery of a new series of compounds that are potent, selective 5-HT(2C) receptor agonists is described herein as we continue our efforts to optimize the 2-phenylcyclopropylmethylamine scaffold. Modifications focused on the alkoxyl substituent present on the aromatic ring led to the identifica...

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Gepubliceerd in:J Med Chem
Hoofdauteurs: Cheng, Jianjun, Giguère, Patrick M., Onajole, Oluseye K., Lv, Wei, Gaisin, Arsen, Gunosewoyo, Hendra, Schmerberg, Claire M., Pogorelov, Vladimir M., Rodriguiz, Ramona M., Vistoli, Giulio, Wetsel, William C., Roth, Bryan L., Kozikowski, Alan P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834193/
https://ncbi.nlm.nih.gov/pubmed/25633969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5019274
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