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Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects in Open Field, Prepulse Inhibition, and Cognition Models

A series of novel compounds with two halogen substituents have been designed and synthesized to further optimize the 2-phenylcyclopropylmethylamine scaffold in the quest for drug-like 5-HT(2C) agonists. Compound (+)-22a was identified as a potent 5-HT(2C) receptor agonist, with good selectivity agai...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Cheng, Jianjun, Giguere, Patrick M., Schmerberg, Claire M., Pogorelov, Vladimir M., Rodriguiz, Ramona M., Wetsel, William C., Roth, Bryan L., Kozikowski, Alan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317212/
https://ncbi.nlm.nih.gov/pubmed/26704965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01153
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