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Designing Functionally Selective Noncatechol Dopamine D(1) Receptor Agonists with Potent In Vivo Antiparkinsonian Activity
Dopamine receptors are important G protein-coupled receptors (GPCRs) with therapeutic opportunities for treating Parkinson’s Disease (PD) motor and cognitive deficits. Biased D(1) dopamine ligands that differentially activate G protein over β-arrestin recruitment pathways are valuable chemical tools...
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| Pubblicato in: | ACS Chem Neurosci |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6785188/ https://ncbi.nlm.nih.gov/pubmed/31387346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00410 |
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