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Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists

[Image: see text] Noncatechol heterocycles have recently been discovered as potent and selective G protein biased dopamine 1 receptor (D1R) agonists with superior pharmacokinetic properties. To determine the structure–activity relationships centered on G protein or β-arrestin signaling bias, systema...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Wang, Pingyuan, Felsing, Daniel E., Chen, Haiying, Raval, Sweta R., Allen, John A., Zhou, Jia
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511950/
https://ncbi.nlm.nih.gov/pubmed/31098001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00050
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