Defining Structure−Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D(1) Receptor Agonists

G protein-coupled receptors (GPCRs) are capable of downstream signaling through distinct noncanonical pathways such as β-arrestins in addition to the canonical G protein-dependent pathways. GPCR ligands that differentially activate the downstream signaling pathways are termed functionally selective...

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發表在:J Med Chem
Main Authors: Martini, Michael L., Liu, Jing, Ray, Caroline, Yu, Xufen, Huang, Xi-Ping, Urs, Aarti, Urs, Nikhil, McCorvy, John D., Caron, Marc G., Roth, Bryan L., Jin, Jian
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688508/
https://ncbi.nlm.nih.gov/pubmed/30875219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00351
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