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Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs
Development of biased ligands targeting G protein-coupled receptors (GPCRs) is a promising approach for current drug discovery. Although structure-based drug design of biased agonists remains challenging even with an abundance of GPCR crystal structures, we present an approach for translating GPCR s...
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| Опубликовано в: : | Nat Chem Biol |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5771956/ https://ncbi.nlm.nih.gov/pubmed/29227473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2527 |
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