Structure-inspired design of β-arrestin-biased ligands for aminergic GPCRs

Development of biased ligands targeting G protein-coupled receptors (GPCRs) is a promising approach for current drug discovery. Although structure-based drug design of biased agonists remains challenging even with an abundance of GPCR crystal structures, we present an approach for translating GPCR s...

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Publicado en:Nat Chem Biol
Autores principales: McCorvy, John D., Butler, Kyle V., Kelly, Brendan, Rechsteiner, Katie, Karpiak, Joel, Betz, Robin M., Kormos, Bethany L., Shoichet, Brian K., Dror, Ron O., Jin, Jian, Roth, Bryan L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5771956/
https://ncbi.nlm.nih.gov/pubmed/29227473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2527
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