ロード中...

Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions

The dopamine D2 receptor (D2R), like many G-protein-coupled receptors, signals through G-protein- and β-arrestin-dependent pathways. Preferential activation of one of these pathways is termed functional selectivity or biased signaling and is a promising therapeutic strategy. Though biased signaling...

詳細記述

保存先:
書誌詳細
出版年:Neuropsychopharmacology
主要な著者: Rose, Samuel J, Pack, Thomas F, Peterson, Sean M, Payne, Kaitlin, Borrelli, Emiliana, Caron, Marc G
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854808/
https://ncbi.nlm.nih.gov/pubmed/29068002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.254
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!